What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits?
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molecules-27-03130.pdf
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1.38 MB
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Checksum (MD5)
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Author(s)
Ratti, Francesca
Magarini, Maurizio
Del Vecchio, Domitilla
Date Issued
May 2022
Journal
Molecules
Publisher
MDPI AG
Citation
Molecules 27 (10): 3130 (2022)
Version
Final published version
Abstract
Information exchange is a critical process in all communication systems, including biological ones. Retroactivity describes the load that downstream modules apply to their upstream systems in biological circuits. The motivation behind this work is that of integrating retroactivity, a concept proper of biochemical circuits, with the metrics defined in Information Theory and Digital Communications. This paper focuses on studying the impact of retroactivity on different biological signaling system models, which present analogies with well-known telecommunication systems. The mathematical analysis is performed both in the high and low molecular counts regime, by mean of the Chemical Master Equation and the Linear Noise Approximation, respectively. The main goal of this work is to provide analytical tools to maximize the reliable information exchange across different biomolecular circuit models. Results highlight how, in general, retroactivity harms communication performance. This negative effect can be mitigated by adding to the signaling circuit an independent upstream system that connects with the same pool of downstream circuits.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/molecules27103130
