Development of quantitative tools for assessment of cerebellar dysfunction
Name
62279581-MIT.pdf
Description
Full printable version
Size
5.3 MB
Format
Adobe PDF
Checksum (MD5)
c7dbd782332816a284b8dab0eded4e87
Author(s)
Garg, Aditi
Advisor(s)
Steve G. Massaquoi.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
Two tools for the quantitative assessment of cerebellar dysfunction are developed and explored. One is based on a battery of laptop tests desgined for clinical use. Extensive analysis of one of the tests using a speed/accuracy trade-off shows a correlation of 0.74 with existing scoring systems. The second involves modeling the cerebellar function in arm movement as a PID controller. Initial results show trends toward asymmetry, higher values for Gk₂₁ and Gk₂₂, and lower values for Gk₁₁ and Gk₁₂ as differences between the controller gains of ataxic subjects and control subjects when analyzing the trajectories of point to point movements. Further insight into these trends may lead to a deeper understanding of the cerebellum's function and dysfunction.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
Includes bibliographical references (p. 55-56).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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