The development of bioresorbable composite polymeric implants with high mechanical strength
Name
Nature_Materials_Revised_-_Main_manuscript_080717.pdf
Description
Accepted version
Size
1.26 MB
Format
Adobe PDF
Checksum (MD5)
3f2b799b9cf93c01eb9bc732de528f44
Author(s)
Sharma, Upma
Concagh, Danny
Core, Lee
Kuang, Yina
You, Changcheng
Pham, Quynh
Zugates, Greg
Busold, Rany
Webber, Stephanie
Merlo, Jonathan
Date Issued
2018
Journal
Nature Materials
Publisher
Springer Nature
Version
Author's final manuscript
Abstract
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Implants for the treatment of tissue defects should mimic the mechanical properties of the native tissue of interest and should be resorbable as well as biocompatible. In this work, we developed a scaffold from variants of poly(glycolic) acid which were braided and coated with an elastomer of poly(glycolide-co-caprolactone) and crosslinked. The coating of the scaffold with the elastomer led to higher mechanical strength in terms of compression, expansion and elasticity compared to braids without the elastomer coating. These composite scaffolds were found to have expansion properties similar to metallic stents, utilizing materials which are typically much weaker than metal. We optimized the mechanical properties of the implant by tuning the elastomer branching structure, crosslink density, and molecular weight. The scaffolds were shown to be highly resorbable following implantation in a porcine femoral artery. Biocompatibility was studied in vivo in an ovine model by implanting the scaffolds into femoral arteries. The scaffolds were able to support an expanded open lumen over 12 months in vivo and also fully resorbed by 18 months in the ovine model.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/NMAT5016
