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Poly(ethylene glycol) with Observable Shedding

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Author(s)
Gao, Weiwei
•
Langer, Robert
•
Farokhzad, Omid C
Date Issued
2010
Journal
Angewandte Chemie - International Edition
Publisher
Wiley
Citation
Gao, W. W., R. Langer, and O. C. Farokhzad. "Poly(Ethylene Glycol) with Observable Shedding." Angewandte Chemie-International Edition 49 37 (2010): 6567-71.
Version
Author's final manuscript
Abstract
A FRET-bearing poly(ethylene glycol) (PEG) conjugate fluoresces at 520 nm when it is cleaved off nanoparticles (NPs; see picture). When the NPs were targeted on cancer cell lines, the reducing endosomal environment caused the cleavage of the disulfide bond and the shedding of the PEG layer. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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DOI of Published Version
10.1002/anie.201001868
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