The dynamic lives of T cells: new approaches and themes
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Love_The dynamic.pdf
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1.39 MB
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Adobe PDF
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aa9613ad2684899f1d12ba62435c951a
Author(s)
Yamanaka, Yvonne J.
Gierahn, Todd Michael
Love, John C
Date Issued
November 2012
Journal
Trends in Immunology
Publisher
Elsevier
Citation
Yamanaka, Yvonne J., Todd M. Gierahn, and J. Christopher Love. “The Dynamic Lives of T Cells: New Approaches and Themes.” Trends in Immunology 34, no. 2 (February 2013): 59–66.
Version
Author's final manuscript
Abstract
Activated T cells have classically been thought to progress unidirectionally through discrete phenotypic states and differentiate into static lineages. It is increasingly evident, however, that T cells exhibit much more complex and flexible dynamic behaviors than initially appreciated, and that these behaviors influence the efficacy of T cell responses to immunological challenges. In this review, we discuss how new technologies for monitoring the dynamics of T cells are enhancing the resolution of the fine phenotypic and functional heterogeneity within populations of T cells and revealing how individual T cells transition among a continuum of states. Such insights into the dynamic properties of T cells should improve immune monitoring and inform strategies for therapeutic interventions.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Ragon Institute of MGH, MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.it.2012.10.006
