Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry
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nihms-1552577.pdf
Description
Accepted version
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3.16 MB
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Author(s)
Correa, Santiago
Boehnke, Natalie
Barberio, Antonio E
Deiss-Yehiely, Elad
Shi, Aria
Oberlton, Benjamin
Smith, Sean G
Zervantonakis, Ioannis
Dreaden, Erik C
Hammond, Paula T
Date Issued
January 2020
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Correa, Santiago, Boehnke, Natalie, Barberio, Antonio E, Deiss-Yehiely, Elad, Shi, Aria et al. 2020. "Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry." ACS Nano, 14 (2).
Version
Author's final manuscript
Abstract
© 2020 American Chemical Society. Nanoparticle surface chemistry is a fundamental engineering parameter that governs tumor-targeting activity. Electrostatic assembly generates controlled polyelectrolyte complexes through the process of adsorption and charge overcompensation utilizing synthetic polyions and natural biomacromolecules; it can yield films with distinctive hydration, charge, and presentation of functional groups. Here, we used electrostatic layer-by-layer (LbL) assembly to screen 10 different surface chemistries for their ability to preferentially target human ovarian cancer in vitro. Our screen identified that poly-l-aspartate, poly-l-glutamate, and hyaluronate-coated LbL nanoparticles have striking specificity for ovarian cancer, while sulfated poly(β-cyclodextrin) nanoparticles target noncancerous stromal cells. We validated top candidates for tumor-homing ability with a murine model of metastatic disease and with patient-derived ovarian cancer spheroids. Nanoparticle surface chemistry also influenced subcellular trafficking, indicating strategies to target the cell membrane, caveolae, and perinuclear vesicles. Our results confirm LbL is a powerful tool to systematically engineer nanoparticles and achieve specific targeting.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
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DOI of Published Version
https://doi.org/10.1021/ACSNANO.9B09213
