Mechanobiology in oncology: basic concepts and clinical prospects
Name
fcell-11-1239749.pdf
Description
Published version
Size
2.21 MB
Format
Adobe PDF
Checksum (MD5)
d4aea63187b0a7328e6d362d47021f23
Author(s)
Chen, Michelle B
Javanmardi, Yousef
Shahreza, Somayeh
Serwinski, Bianca
Aref, Amir
Djordjevic, Boris
Moeendarbary, Emad
Date Issued
October 31, 2023
Journal
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Citation
Chen MB, Javanmardi Y, Shahreza S, Serwinski B, Aref A, Djordjevic B and Moeendarbary E (2023) Mechanobiology in oncology: basic concepts and clinical prospects. Front. Cell Dev. Biol. 11:1239749.
Version
Final published version
Abstract
The interplay between genetic transformations, biochemical communications, and physical interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related deaths, involves a series of steps, including invasion, intravasation, circulation survival, and extravasation. Mechanical alterations, such as changes in stiffness and morphology, play a significant role in all stages of cancer initiation and dissemination. Accordingly, a better understanding of cancer mechanobiology can help in the development of novel therapeutic strategies. Targeting the physical properties of tumours and their microenvironment presents opportunities for intervention. Advancements in imaging techniques and lab-on-a-chip systems enable personalized investigations of tumor biomechanics and drug screening. Investigation of the interplay between genetic, biochemical, and mechanical factors, which is of crucial importance in cancer progression, offers insights for personalized medicine and innovative treatment strategies.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fcell.2023.1239749
