Advances in discovering small molecules to probe protein function in a systems context
Name
Advances in discovering.pdf
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517.99 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Doyle, Shelby Kathleen
Pop, Marius S
Evans, Helen L
Koehler, Angela Nicole
Date Issued
November 2015
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Citation
Doyle, Shelby K et al. “Advances in Discovering Small Molecules to Probe Protein Function in a Systems Context.” Current Opinion in Chemical Biology 30 (2016): 28–36.
Version
Author's final manuscript
Abstract
High throughput screening (HTS) has historically been used for drug discovery almost exclusively by the pharmaceutical industry. Due to a significant decrease in costs associated with establishing a high throughput facility and an exponential interest in discovering probes of development and disease associated biomolecules, HTS core facilities have become an integral part of most academic and non-profit research institutions over the past decade. This major shift has led to the development of new HTS methodologies extending beyond the capabilities and target classes used in classical drug discovery approaches such as traditional enzymatic activity-based screens. In this brief review we describe some of the most interesting developments in HTS technologies and methods for chemical probe discovery.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cbpa.2015.10.032
