Melanoma resistance to photodynamic therapy: new insights
Name
Huang-2013-Melanoma resistance.pdf
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1.31 MB
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Adobe PDF
Checksum (MD5)
71264624fbbdcd3123b61988af5c0034
Author(s)
Huang, Ying-Ying
Vecchio, Daniela
Avci, Pinar
Yin, Rui
Garcia-Diaz, Maria
Hamblin, Michael R.
Date Issued
February 2013
Journal
Biological Chemistry
Publisher
Walter de Gruyter
Citation
Huang, Ying-Ying, Daniela Vecchio, Pinar Avci, Rui Yin, Maria Garcia-Diaz, and Michael R. Hamblin. “Melanoma Resistance to Photodynamic Therapy: New Insights.” Biological Chemistry 394, no. 2 (January 1, 2013).
Version
Final published version
Abstract
Melanoma is the most dangerous form of skin cancer, with a steeply rising incidence and a poor prognosis in its advanced stages. Melanoma is highly resistant to traditional chemotherapy and radiotherapy, although modern targeted therapies such as BRAF inhibitors are showing some promise. Photodynamic therapy (PDT, the combination of photosensitizing dyes and visible light) has been tested in the treatment of melanoma with some promising results, but melanoma is generally considered to be resistant to it. Optical interference by the highly-pigmented melanin, the antioxidant effect of melanin, the sequestration of photosensitizers inside melanosomes, defects in apoptotic pathways, and the efflux of photosensitizers by ATP-binding cassette transporters have all been implicated in melanoma resistance to PDT. Approaches to overcoming melanoma resistance to PDT include: the discovery of highly active photosensitizers absorbing in the 700–800-nm near infrared spectral region; interventions that can temporarily reduce the amount or pigmentation of the melanin; compounds that can reverse apoptotic defects or inhibit drug-efflux of photosensitizers; and immunotherapy approaches that can take advantage of the ability of PDT to activate the host immune system against the tumor being treated.
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1515/hsz-2012-0228
