In vivo profiles in malaria are consistent with a novel physiological state
Name
Wirth-2009-In vivo profiles in.pdf
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Author(s)
Wirth, Dyann
Daily, Johanna P.
Winzeler, Elizabeth
Mesirov, Jill P.
Regev, Aviv
Date Issued
July 2009
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences
Citation
Wirth, Dyann et al. “In vivo profiles in malaria are consistent with a novel physiological state.” Proceedings of the National Academy of Sciences 106.27 (2009): E70. ©2009 the National Academy of Sciences
Version
Final published version
Abstract
Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation between Cluster 1 and gametogenesis). However, Lemieux et al. (1) fit the observed in vivo profiles as a mixture of gametocyte and asexual form mRNA (Fig. 2E in ref. 1), concluding that the discrete clusters are consistent with varying proportions of sexually committed but phenotypically indistinguishable parasites, reflected by the parameter α.
MIT Department
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.1073/pnas.0904478106
