A Circuitous Route to Noncoding RNA
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Sharp_Molecular biology.pdf
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300.06 KB
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Adobe PDF
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Author(s)
Sharp, Phillip A.
Wilusz, Jeremy
Date Issued
April 2013
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Wilusz, J. E., and P. A. Sharp. “A Circuitous Route to Noncoding RNA.” Science 340, no. 6131 (April 25, 2013): 440–441.
Version
Author's final manuscript
Abstract
Most genetic information is expressed as, and transacted by, proteins. Yet, less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% of the genome, once considered to be mostly “junk DNA.” Transcription is pervasive, however, and high-throughput sequencing has identified tens of thousands of distinct RNAs generated from the non—protein—coding portion of the genome (1). These so-called noncoding RNAs vary in length, but like protein-coding RNAs, appear to be linear molecules with 5′ and 3′ termini, reflecting the defined start and end points of RNA polymerase on the DNA template. But do all RNAs have to be linear?
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.1238522
