A twist in the tail: Of T cell subsets and disease
Name
jem_20231423.pdf
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785.81 KB
Format
Adobe PDF
Checksum (MD5)
fe9d5a9eb190921decede7cef0d22e63
Author(s)
Pillai, Shiv
Date Issued
November 6, 2023
Journal
Journal of Experimental Medicine
Publisher
Rockefeller University Press
Citation
Shiv Pillai; A twist in the tail: Of T cell subsets and disease. J Exp Med 6 November 2023; 220 (11): e20231423.
Version
Final published version
Abstract
A point mutation in the cytoplasmic tail of a key T cell signaling adaptor resulted in a rodent disease model that resembles a human fibrotic inflammatory disease that has served as a prototype for a set of human diseases driven by cytotoxic CD4+ T cells. These diseases cannot be categorized using the widely used type 1, type 2, and type 3 immune mechanism paradigms.
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Creative Commons Attribution-NonCommercial-ShareAlike
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DOI of Published Version
https://doi.org/10.1084/jem.20231423
