Silencing and recombination in yeast ribosomal DNA
Name
317950968-MIT.pdf
Description
Full printable version
Size
40.42 MB
Format
Adobe PDF
Checksum (MD5)
bafda4d38a58bf66542271c8075fc242
Author(s)
O'Kelly, Michael J. T
Advisor(s)
Alexander van Oudenaarden.
Date Issued
2008
Publisher
Massachusetts Institute of Technology
Abstract
A bioinformatic and laboratory investigation into S. cerevisiae's system for the maintenance and homogenization of rDNA. Eliminating mutations and heterogeneity in rDNA repeats is necessary evolutionarily, but harmful to individual organisms--and has been linked to aging-related pathology. We present a forensic investigation of this process using a new whole-genome shotgun dataset, and interpret the results in light of experimental results showing the dynamics of rDNA silencing and recombination in laboratory strains.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 2008.
Includes bibliographical references (p. 129-132).
Subjects
Physics.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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reproduction or distribution in any format is prohibited without written
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