Development and study of synthetic polypeptides for biomaterial applications
Name
861621344-MIT.pdf
Description
Full printable version
Size
2.77 MB
Format
Adobe PDF
Checksum (MD5)
a7a16c4902800aee9acdc3f7de3b101b
Author(s)
Morey, Shannon Marie
Advisor(s)
Paula T. Hammond.
Date Issued
2013
Publisher
Massachusetts Institute of Technology
Abstract
Creating new scaffolds for cells is critical to the development of new tissue engineering techniques. In this work, the synthesis of new polypeptide systems is discussed. These systems are intended for the formation of hydrogels which can then be used as cell substrates. Attempts at using the clickable synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic polypeptide with click functionality is also investigated. Additionally, the creation of a polypeptide system with two functionalities available for orthogonal click chemistry is discussed.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.
Vita. Cataloged from PDF version of thesis.
Includes bibliographical references (p. 38-39).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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reproduction or distribution in any format is prohibited without written
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