Hydrolysis resistant functional polypeptide scaffold for biomaterials
Author(s)
Wang, Wade
Hammond, Paula T
Date Issued
2018
Journal
Polymer Chemistry
Publisher
Royal Society of Chemistry (RSC)
Citation
Wang, Wade and Paula T. Hammond et al. "Hydrolysis resistant functional polypeptide scaffold for biomaterials." Polymer Chemistry 9, 3 (2018): 346-351 © 2018 The Royal Society of Chemistry
Version
Author's final manuscript
Abstract
For biomaterials, rich functionality often comes at a cost of precise control over structure. In this paper, we have developed a hydrolysis resistant polypeptide that marries the potential for expansive modification with synthetic control. This polymer, poly(γ-propargyl-l-glutamine) may be prepared from commercially available or previously synthesized poly(l-glutamate) by routine amide bond coupling reactions on a multi gram scale. Afterwards, the polymer may be altered to suit many applications through modification of the side chains or end group by orthogonal and quantitative reactions. The ease of synthesis and versatile nature of poly(γ-propargyl-l-glutamine) makes it a unique and ideal scaffold for biomaterial applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c7py01586k
