Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation
Name
nihms-1535066.pdf
Description
Accepted version
Size
3 MB
Format
Adobe PDF
Checksum (MD5)
3d0a2c9f17c71a13192bb8e2c1c45835
Author(s)
Brubaker, Douglas
Paulo, Joao A.
Sheth, Shikha
Poulin, Emily J.
Popow, Olesja
Joughin, Brian Alan
Strasser, Samantha Dale
Starchenko, Alina
Gygi, Steven P.
Lauffenburger, Douglas A
Date Issued
September 2019
Journal
Cell Systems
Publisher
Elsevier BV
Citation
Brubaker, Douglas K. et al. "Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation." Cell Systems 9, 3 (September 2019): 733-739 © 2019 Elsevier Inc.
Version
Author's final manuscript
Abstract
To better understand how tissue context contributes to cancer-specific signaling by the same protein, Brubaker and Paulo et al. performed mass-spectrometry-based analysis of total and phosphoproteomic datasets from four murine tissues with mutationally activated K-RAS and developed computational techniques to translate mouse signaling insights to patient tumors.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cels.2019.07.006
