The evolution of metazoan extracellular matrix
Name
Hynes-2012-The evolution of met.pdf
Size
1.59 MB
Format
Adobe PDF
Checksum (MD5)
1ba550c251ef48df312222f511910a47
Author(s)
Hynes, Richard O
Date Issued
March 2012
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press, The
Citation
Hynes, R. O. “Evolution: The Evolution of Metazoan Extracellular Matrix.” The Journal of Cell Biology 196.6 (2012): 671–679. Web. 4 May 2012.
Version
Final published version
Abstract
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1083/jcb.201109041
