End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
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End-to-End continuous Manufacturing of Pharmaceuticals Integrated Synthesis, Purification, and Final Dosage Formation.docx
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636.36 KB
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Checksum (MD5)
c7fbc26e30c4bb2a2e273eb612f5d6d8
Author(s)
Mascia, Salvatore
Heider, Patrick L.
Zhang, Haitao
Lakerveld, Richard
Benyahia, Brahim
Barton, Paul I.
Braatz, Richard D.
Cooney, Charles L.
Evans, James M. B.
Jamison, Timothy F.
Jensen, Klavs F.
Myerson, Allan S.
Trout, Bernhardt L.
Date Issued
October 2013
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Mascia, Salvatore, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, et al. “End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation.” Angewandte Chemie International Edition 52, no. 47 (October 2, 2013): 12359–12363.
Version
Original manuscript
Abstract
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
http://dx.doi.org/10.1002/anie.201305429
