Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering
Name
nihms-1772203.pdf
Description
Accepted version
Size
2.38 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Sharifi, Sina
Sharifi, Hannah
Akbari, Ali
Dohlman, Claes H
Paschalis, Eleftherios I
Gonzalez-Andrades, Miguel
Kong, Jing
Chodosh, James
Date Issued
2021
Journal
ACS Applied Nano Materials
Publisher
American Chemical Society (ACS)
Citation
Sharifi, Sina, Sharifi, Hannah, Akbari, Ali, Dohlman, Claes H, Paschalis, Eleftherios I et al. 2021. "Graphene-Lined Porous Gelatin Glycidyl Methacrylate Hydrogels: Implications for Tissue Engineering." ACS Applied Nano Materials, 4 (11).
Version
Author's final manuscript
Abstract
Despite rigorous research, inferior mechanical properties and structural homogeneity are the main challenges constraining hydrogel's suturability to host tissue and limiting its clinical applications. To tackle those, we developed a reverse solvent interface trapping method, in which organized, graphene-coated microspherical cavities were introduced into a hydrogel to create heterogeneity and make it suturable. To generate those cavities, (i) graphite exfoliates to graphene sheets, which spread at the water/ heptane interfaces of the microemulsion, (ii) heptane fills the microspheres coated by graphene, and (iii) a cross-linkable hydrogel dissolved in water fills the voids. Cross-linking solidifies such microemulsion to a strong, suturable, permanent hybrid architecture, which has better mechanical properties, yet it is biocompatible and supports cell adhesion and proliferation. These properties along with the ease and biosafety of fabrication suggest the potential of this strategy to enhance tissue engineering outcomes by generating various suturable scaffolds for biomedical applications, such as donor cornea carriers for Boston keratoprosthesis (BK).
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1021/ACSANM.1C03201
