Towards a Prime Factorization of Proteins
Name
radev-sradev-SM-MAS-2024-thesis.pdf
Description
Thesis PDF
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11.89 MB
Format
Adobe PDF
Checksum (MD5)
c352d7c1659879f354011f39a727d5ab
Author(s)
Radev, Simeon
Advisor(s)
Jacobson, Joseph
Date Issued
May 2024
Publisher
Massachusetts Institute of Technology
Abstract
A classical problem of machine learning is the interpretability of a model’s latent information processing. This is particularly the case in the richly complex field of protein analysis, whereby unique and novel insights into the structural organization of proteins can help illuminate their functional space, and in particular lead toward a factorization of the structural space into a set of motif building blocks, which completely span this universe. This thesis creates a new inference interface for performing such analysis, by leveraging the sequential learning process of a neural autoencoder to construct a decomposition of proteins as a hierarchical sequence of embedded representation vectors. The further development of this work could lead to a greater understanding of the organizational complexity of natural phenomena, and in particular, as it relates to the uniquely complex relationship between protein structures and their function.
MIT Department
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
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