B7-H5 costimulates human T cells via CD28H
Name
Chen_B7-H5 costimulates.pdf
Size
4.9 MB
Format
Adobe PDF
Checksum (MD5)
1a0e55eb3a99b7d8c8572579fb2c3cb9
Author(s)
Zhu, Yuwen
Yao, Sheng
Iliopoulou, Bettina P.
Han, Xue
Augustine, Mathew M.
Xu, Haiying
Phennicie, Ryan T.
Flies, Sarah J.
Broadwater, Megan
Ruff, William
Date Issued
June 2013
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Zhu, Yuwen, Sheng Yao, Bettina P. Iliopoulou, Xue Han, Mathew M. Augustine, Haiying Xu, Ryan T. Phennicie, et al. “B7-H5 costimulates human T cells via CD28H.” Nature Communications 4 (June 19, 2013).
Version
Author's final manuscript
Abstract
The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new CD28 homologue (CD28H) that has unique functions in the regulation of the human immune response and is absent in mice. CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. B7-H5 is constitutively found in macrophages and could be induced on dendritic cells. The B7-H5/CD28H interaction selectively costimulates human T-cell growth and cytokine production via an AKT-dependent signalling cascade. Our study identifies a novel costimulatory pathway regulating human T-cell responses.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/ncomms3043
