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Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
Name
s41467-019-09382-9.pdf
Description
Published version
Size
8.15 MB
Format
Adobe PDF
Checksum (MD5)
62c9e0d5a7aed2fd8c46cc7a0d5e78b7
Author(s)
Edfawy, Mohamed
Guedes, Joana R
Pereira, Marta I
Laranjo, Mariana
Carvalho, Mário J
Gao, Xian
Ferreira, Pedro A
Caldeira, Gladys
Franco, Lara O
Wang, Dongqing
Date Issued
2019
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Version
Final published version
Abstract
© 2019, The Author(s). Autism spectrum disorder (ASD) is characterized by dysfunction in social interactions, stereotypical behaviours and high co-morbidity with intellectual disability. A variety of syndromic and non-syndromic neurodevelopmental disorders have been connected to alterations in metabotropic glutamate receptor (mGluR) signalling. These receptors contribute to synaptic plasticity, spine maturation and circuit development. Here, we investigate the physiological role of Gprasp2, a gene linked to neurodevelopmental disabilities and involved in the postendocytic sorting of G-protein-coupled receptors. We show that Gprasp2 deletion leads to ASD-like behaviour in mice and alterations in synaptic communication. Manipulating the levels of Gprasp2 bidirectionally modulates the surface availability of mGluR 5 and produces alterations in dendritic complexity, spine density and synaptic maturation. Loss of Gprasp2 leads to enhanced hippocampal long-term depression, consistent with facilitated mGluR-dependent activation. These findings demonstrate a role for Gprasp2 in glutamatergic synapses and suggest a possible mechanism by which this gene is linked to neurodevelopmental diseases.
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
10.1038/s41467-019-09382-9
