Manufacturing methods for high density micro-channel arrays
Name
46309869-MIT.pdf
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Full printable version
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25.36 MB
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2bfe31b1b1a6d19c2e2c0ddd3bfef022
Author(s)
Sosnowski, Luke P. (Luke Piotr), 1976-
Advisor(s)
Ian W. Hunter.
Date Issued
2000
Publisher
Massachusetts Institute of Technology
Abstract
This thesis explores two distinct methods of micro-array manufacture for high throughput pharmaceutical scanning. The first method, impact shaping of polymers, is a novel, inexpensive way to form large numbers of small channels or wells in plastics. The impact method uses the kinetic energy from a ram to punch holes into a polymer sample without melting the bulk of the workpiece. The second method is electrical discharge machining (EDM) of silicon, which machines high aspect ratio holes arranged in high density arrays on silicon wafers. The method may be viewed as complementary to current plasma etching techniques and lithography. Several testing platforms were devised for the creation of the plastic well arrays based on the high speed ram principle. A modified Charmilles Roboform 30 machine was used to create the silicon arrays. While creating high volume manufacturing methods for will required additional work, both processes were fundamentally successful, producing individual arrays of acceptable quality. Both methods hold promise for manufacture of accurate, inexpensive, and useful replacements for current plate technology.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
Includes bibliographical references (leaves 124-127).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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