Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation
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Feng_Sensory integration.pdf
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Author(s)
Gogolla, Nadine
Takesian, Anne E.
Feng, Guoping
Fagiolini, Michela
Hensch, Takao K.
Date Issued
July 2014
Journal
Neuron
Publisher
Elsevier
Citation
Gogolla, Nadine, Anne E. Takesian, Guoping Feng, Michela Fagiolini, and Takao K. Hensch. “Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation.” Neuron 83, no. 4 (August 2014): 894–905.
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Author's final manuscript
Abstract
Insular cortex (IC) contributes to a variety of complex brain functions, such as communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive content. How the IC acquires its integrative properties remains unexplored. We compared the emergence of multisensory integration (MSI) in the IC of behaviorally distinct mouse strains. While adult C57BL/6 mice exhibited robust MSI, this capacity was impaired in the inbred BTBR T+tf/J mouse model of idiopathic autism. The deficit reflected weakened γ-aminobutyric acid (GABA) circuits and compromised postnatal pruning of cross-modal input. Transient pharmacological enhancement by diazepam in BTBR mice during an early sensitive period rescued inhibition and integration in the adult IC. Moreover, impaired MSI was common across three other monogenic models (GAD65, Shank3, and Mecp2 knockout mice) displaying behavioral phenotypes and parvalbumin-circuit abnormalities. Our findings offer developmental insight into a key neural circuit relevant to neuropsychiatric conditions like schizophrenia and autism.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2014.06.033
