Selective transfer of maternal antibodies in preterm and fullterm children
Name
s41598-022-18973-4.pdf
Description
Published version
Size
2.1 MB
Format
Adobe PDF
Checksum (MD5)
3458942be3835f75decf44b8eccac365
Author(s)
Dolatshahi, Sepideh
Butler, Audrey L
Pou, Christian
Henckel, Ewa
Bernhardsson, Anna Karin
Gustafsson, Anna
Bohlin, Kajsa
Shin, Sally A
Lauffenburger, Douglas A
Brodin, Petter
Date Issued
2022
Journal
Scientific Reports
Publisher
Springer Science and Business Media LLC
Citation
Dolatshahi, Sepideh, Butler, Audrey L, Pou, Christian, Henckel, Ewa, Bernhardsson, Anna Karin et al. 2022. "Selective transfer of maternal antibodies in preterm and fullterm children." Scientific Reports, 12 (1).
Version
Final published version
Abstract
Preterm newborns are more likely to suffer from infectious diseases at birth compared to children delivered at term. Whether this is due to compromised cellular, humoral, or organ-specific development remains unclear. To begin to define whether maternal–fetal antibody transfer profiles differ across preterm (PT) and fullterm (FT) infants, the overall quantity and functional quality of an array of 24 vaccine-, endemic pathogen-, and common antigen-specific antibodies were assessed across a cohort of 11 PT and 12 term-delivered maternal:infant pairs from birth through week 12. While total IgG levels to influenza, pneumo, measles, rubella, EBV, and RSV were higher in FT newborns, selective Fc-receptor binding antibodies was noted in PT newborns. In fact, near equivalent antibody-effector functions were observed across PT and FT infants, despite significant quantitative differences in transferred antibody levels. Moreover, temporal transfer analysis revealed the selective early transfer of FcRn, FcγR2, and FcγR3 binding antibodies, pointing to differential placental sieving mechanisms across gestation. These data point to selectivity in placental transfer at distinct gestational ages, to ensure that children are endowed with the most robust humoral immunity even if born preterm.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/S41598-022-18973-4
