Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex
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Nedivi_Highly specific.pdf
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Author(s)
Chen, Jerry L.
Nedivi, Elly
Date Issued
March 2013
Journal
The Neuroscientist
Publisher
Sage Publications
Citation
Chen, J. L., and E. Nedivi. “Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex.” The Neuroscientist 19, no. 4 (August 1, 2013): 384–93.
Version
Author's final manuscript
Abstract
Inhibitory neurons are known to play a vital role in defining the window for critical period plasticity during development, and it is increasingly apparent that they continue to exert powerful control over experience-dependent cortical plasticity in adulthood. Recent in vivo imaging studies demonstrate that long-term plasticity of inhibitory circuits is manifested at an anatomical level. Changes in sensory experience drive structural remodeling in inhibitory interneurons in a cell-type and circuit-specific manner. Inhibitory synapse formation and elimination can occur with a great deal of spatial and temporal precision and are locally coordinated with excitatory synaptic changes on the same neuron. We suggest that the specificity of inhibitory synapse dynamics may serve to differentially modulate activity across the dendritic arbor, to selectively tune parts of a local circuit, or potentially discriminate between activities in distinct local circuits. We further review evidence suggesting that inhibitory circuit structural changes instruct excitatory/inhibitory balance while enabling functional reorganization to occur through Hebbian forms of plasticity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1177/1073858413479824
