The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined
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10741_2024_10463_ReferencePDF.pdf
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1.01 MB
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Author(s)
Jiang, Haoran
Kittipibul, Veraprapas
Mahfoud, Felix
Böhm, Michael
Sobotka, Paul A.
Esler, Murray
Wang, Jie
Fudim, Marat
Date Issued
November 7, 2024
Journal
Heart Failure Reviews
Publisher
Springer US
Citation
Jiang, H., Kittipibul, V., Mahfoud, F. et al. The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined. Heart Fail Rev 30, 293–314 (2025).
Version
Author's final manuscript
Abstract
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interruption of sympathetic nerves connecting the kidney and the sympathetic nervous system can reduce blood pressure. Here, we present a review on how renal denervation can help hypertension patients, specifically focusing on our novel understanding of renal nerve anatomy, denervation technique, and subsequent clinical trials, and how it may be used to treat other cardiovascular diseases like heart failure.
MIT Department
Institute for Medical Engineering and Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s10741-024-10463-1
