7.340 Ubiquitination: The Proteasome and Human Disease, Fall 2004
Author(s)
Rubio, Marta
Alternative Title
Ubiquitination: The Proteasome and Human Disease
Date Issued
December 2004
Abstract
This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, speculation on the novel techniques that arose from an increased knowledge of the ubiquitin-proteosome system and current applications in the design of new pharmacological agents to battle disease is also covered.
Subjects
ubiquitination
ubiquitin
proteasome
post-translational mechanisms
ubiquitin-conjugation system
neurodegenerative diseases
immune response
cell cycle regulation
apoptosis
signal transduction pathways
tumorigenesis
protein degradation
Endoplasmic Reticulum Associated Degradation Pathway
ligases
translocated proteins
misfolded proteins
trafficking membranes
cell cycle control
programmed cell death
Huntington's Disease
Von Hippel-Lindau Disease
MIT Department
Massachusetts Institute of Technology. Department of Biology
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