Overcoming Challenges in Cellular Therapies: A Systems Engineering Approach for Equitable Access
Name
latouche-edulat-sm-sdm-2024-thesis.pdf
Description
Thesis PDF
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6 MB
Format
Adobe PDF
Checksum (MD5)
204ce1be1216bf32995ac245cb6ad627
Author(s)
Latouche, Eduardo Luis
Advisor(s)
Rubin, Joan
Date Issued
May 2024
Publisher
Massachusetts Institute of Technology
Abstract
Cellular and gene therapies have ushered in a new era of medical treatment, promising cures previously thought unattainable. Technologies like CRISPR/Cas9 enable precise genome manipulation, yet challenges persist in therapy delivery, prompting the rise of ex vivo approaches. Despite the promise of adaptive cell therapies, high development costs, manufacturing complexities, and regulatory hurdles hinder widespread adoption. The lack of agreement in the field with respect to centralized versus decentralized manufacturing models and the choice between autologous and allogeneic cell sources pose additional challenges. Equally as critical for global access to these therapies, personnel shortages and specialized expertise requirements must be addressed. A systems engineering approach offers a framework for overcoming these barriers, facilitating comprehensive bioprocess design analysis. Ultimately, developing a descriptive model for analyzing therapeutic delivery is crucial for ensuring equitable access to these transformative therapies worldwide.
MIT Department
System Design and Management Program.
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In Copyright - Educational Use Permitted
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