Active scaffolds for on-demand drug and cell delivery
Name
Zhao-2011-Jan-Active scaffolds for on-demand drug and cell delivery.pdf
Size
1.4 MB
Format
Adobe PDF
Checksum (MD5)
416c4066af77b0d0bccd3c187f0d5515
Author(s)
Zhao, Xuanhe
Kim, Jaeyun
Cezar, Christine A.
Huebsch, Nathaniel David
Lee, Kangwon
Bouhadir, Kamal
Mooney, David J.
Date Issued
January 2011
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publisher
National Academy of Sciences (U.S.)
Citation
Zhao, X. et al. “Active Scaffolds for On-demand Drug and Cell Delivery.” Proceedings of the National Academy of Sciences 108.1 (2011) : 67-72.©2011 by the National Academy of Sciences.
Version
Final published version
Abstract
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1007862108
