Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
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41573_2023_Article_670.pdf
Description
Published version
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2.83 MB
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Adobe PDF
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Author(s)
Baryakova, Tsvetelina H
Pogostin, Brett H
Langer, Robert
McHugh, Kevin J
Date Issued
March 27, 2023
Journal
Nature Reviews Drug Discovery
Publisher
Springer Science and Business Media LLC
Citation
Baryakova, T.H., Pogostin, B.H., Langer, R. et al. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nat Rev Drug Discov 22, 387–409 (2023).
Version
Final published version
Abstract
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have proved to be prohibitively complex and/or ineffective. Formulating a pharmaceutical in a drug delivery system (DDS) is a promising alternative that can directly mitigate many common impediments to adherence, including frequent dosing, adverse effects and a delayed onset of action. Existing DDSs have already positively influenced patient acceptability and improved rates of adherence across various disease and intervention types. The next generation of systems have the potential to instate an even more radical paradigm shift by, for example, permitting oral delivery of biomacromolecules, allowing for autonomous dose regulation and enabling several doses to be mimicked with a single administration. Their success, however, is contingent on their ability to address the problems that have made DDSs unsuccessful in the past.
Description
Provided to the PMC Covid-19 Collection by Springer Nature
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/s41573-023-00670-0
