Modeling and analysis of single-molecule experiments
Name
64551507-MIT.pdf
Description
Full printable version
Size
13.18 MB
Format
Adobe PDF
Checksum (MD5)
56454948b531f8c0ac9fbedca1535cf6
Author(s)
Witkoskie, James B
Advisor(s)
Jianshu Cao.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
Single molecule experiments offer a unique window into the molecular world. This window allows us to distinguish the behaviors of individual molecules from the behavior of bulk by observing rare events and heterogeneity in the dynamics. This thesis discusses both models for single molecule experiments, including the stretching of DNA in hydrodynamic flows and the diffusion of tracer particles in heterogeneous environments, and methods to analyze single molecule data to allow determination of properties and models for single molecule experiments. These methods of analysis are based on combining information theory and Bayesian methods with physical insight and are applied to several experimental situations.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.
Vita.
Includes bibliographical references (p. 281-311).
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
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