Locating and classifying fluorescent tags behind turbid layers using time-resolved inversion
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Bawendi_Locating and classifying.pdf
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Author(s)
Satat, Guy
Heshmat Dehkordi, Barmak
Barsi, Christopher
Raviv, Dan
Chen, Ou
Bawendi, Moungi G
Raskar, Ramesh
Date Issued
April 2015
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Satat, Guy; Heshmat, Barmak; Barsi, Christopher; Raviv, Dan; Chen, Ou; Bawendi, Moungi G. and Raskar, Ramesh. “Locating and Classifying Fluorescent Tags Behind Turbid Layers Using Time-Resolved Inversion.” Nature Communications 6, 6796 (April 2015): 1-8 © 2015 Macmillan Publishers Limited
Version
Author's final manuscript
Abstract
The use of fluorescent probes and the recovery of their lifetimes allow for significant advances in many imaging systems, in particular, medical imaging systems. Here we propose and experimentally demonstrate reconstructing the locations and lifetimes of fluorescent markers hidden behind a turbid layer. This opens the door to various applications for non-invasive diagnosis, analysis, flowmetry and inspection. The method is based on a time-resolved measurement that captures information about both fluorescence lifetime and spatial position of the probes. To reconstruct the scene, the method relies on a sparse optimization framework to invert time-resolved measurements. This wide-angle technique does not rely on coherence, and does not require the probes to be directly in line of sight of the camera, making it potentially suitable for long-range imaging.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Media Laboratory
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/ncomms7796
