Synthetic biology strategies for improving microbial synthesis of “green” biopolymers
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6acbbd403aab409c05f12429079aeb8c0632.pdf
Description
Accepted version
Size
908.79 KB
Format
Adobe PDF
Checksum (MD5)
42571286f3a20e6cef17e9d0b891bb65
Author(s)
Anderson, Lisa A
Islam, M. Ahsanul
Prather, Kristala L
Date Issued
January 2018
Journal
Journal of Biological Chemistry
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Citation
Anderson, Lisa A. et al. "Synthetic biology strategies for improving microbial synthesis of “green” biopolymers."Journal of Biological Chemistry 293, 14 (January 2018): 5053-5061 © 2018 American Society for Biochemistry and Molecular Biology
Version
Author's final manuscript
Abstract
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select “green” biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed. Taken together, microbial engineering has expanded the repertoire of green biological chemistry by increasing the diversity of biobased materials.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Synthetic Biology Center
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1074/jbc.tm117.000368
