Biomolecular Modeling at Scale
Name
wohlwend-jw2016-phd-eecs-2025-thesis.pdf
Description
Thesis PDF
Size
9.67 MB
Format
Adobe PDF
Checksum (MD5)
fab5e6969b8835962e3b1dd4982c4f85
Author(s)
Wohlwend, Jeremy
Advisor(s)
Barzilay, Regina
Date Issued
May 2025
Publisher
Massachusetts Institute of Technology
Abstract
Predicting the structure and interactions of biomolecules is a fundamental problem in computational biology, with broad implications for disease understanding and drug discovery. Advances in deep learning have enabled remarkable progress, but scaling these approaches to the varied and complex realities of biology is a persistent challenge. This work introduces deep learning methods for biomolecular modeling at scale, designed for efficiency, adaptability, and accessibility. The early chapters present models developed in the general molecular domain, including prediction of structure and interactions for proteins, nucleic acids, and small molecules. To demonstrate how these methods extend to specific biological problems, the latter portion of this work focuses on modeling T cell receptor recognition. As a key immunological mechanism, it highlights the promise of scalable models, but also their present limitations in capturing fine-grained molecular selectivity. Together, these contributions define a framework for bridging foundational models and domain-specific applications, with the potential to scale, and meet the demands of increasingly complex biological systems.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Attribution 4.0 International (CC BY 4.0)
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