A multilayered microfluidic blood vessel-like structure
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10544_2015_Article_9993.pdf
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4.07 MB
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Checksum (MD5)
7d95a983a5d3aa73e910bbc453051647
Author(s)
Hasan, Anwarul
Paul, Arghya
Memic, Adnan
Khademhosseini, Ali
Date Issued
August 2015
Journal
Biomedical Microdevices
Publisher
Springer US
Citation
Hasan, Anwarul et al. “A Multilayered Microfluidic Blood Vessel-like Structure.” Biomedical Microdevices 17.5 (2015): n. pag.
Version
Author's final manuscript
Abstract
There is an immense need for tissue engineered blood vessels. However, current tissue engineering approaches still lack the ability to build native blood vessel-like perfusable structures with multi-layered vascular walls. This paper demonstrated a new method to fabricate tri-layer biomimetic blood vessel-like structures on a microfluidic platform using photocrosslinkable gelatin hydrogel. The presented method enables fabrication of physiological blood vessel-like structures with mono-, bi- or tri-layer vascular walls. The diameter of the vessels, the total thickness of the vessel wall and the thickness of each individual layer of the wall were independently controlled. The developed fabrication process is a simple and rapid method, allowing the physical fabrication of the vascular structure in minutes, and the formation of a vascular endothelial cell layer inside the vessels in 3–5 days. The fabricated vascular constructs can potentially be used in numerous applications including drug screening, development of in vitro models for cardiovascular diseases and/or cancer metastasis, and study of vascular biology and mechanobiology.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s10544-015-9993-2
