Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
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Olsen_Enhanced activity.pdf
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Author(s)
Kim, Minkyu
Huang, Aaron
Kang, Jeon Woong
Suthiwangcharoen, Nisaraporn
Nagarajan, Ramanathan
Gkikas, Emmanouil
Olsen, Bradley D
Date Issued
February 2014
Journal
Chemical Communications
Publisher
Royal Society of Chemistry
Citation
Kim, Minkyu, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, and Bradley D. Olsen. “Enhanced Activity and Stability of Organophosphorus Hydrolase via Interaction with an Amphiphilic Polymer.” Chem. Commun. 50, no. 40 (2014): 5345.
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Author's final manuscript
Abstract
A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Laser Biomedical Research Center
Massachusetts Institute of Technology. Spectroscopy Laboratory
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DOI of Published Version
https://doi.org/10.1039/c3cc47675h
