The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders
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Mellios-2012-The Emerging Role of.pdf
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Author(s)
Mellios, Nikolaos
Sur, Mriganka
Date Issued
April 2012
Journal
Frontiers in Psychiatry
Publisher
Frontiers Research Foundation
Citation
Mellios, Nikolaos, and Mriganka Sur. “The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders.” Frontiers in Psychiatry 3 (2012).
Version
Final published version
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.3389/fpsyt.2012.00039
