Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients
Name
Mark1Proton Pump Inhibitor Use Is not Associated with Cardiac Arrhythmia in Critically Ill Patients - 1028.pdf
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Author(s)
Chen, Kenneth P.
Malley, Brian E.
Danziger, John
Lee, Joonwu
Mark, Roger G
Feng, Mengling
Celi, Leo Anthony G.
Date Issued
March 2015
Journal
Journal of Clinical Pharmacology
Publisher
John Wiley & Sons, Inc.
Citation
Chen, K. P., Lee, J., Mark, R. G., Feng, M., Celi, L. A., Malley, B. E. and Danziger, J. (2015), "Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients." Journal of Clinical Pharmacology, 55: 774-779.
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Author's final manuscript
Abstract
Hypomagnesemia can lead to cardiac arrythmias. Recently, observational data have linked chronic proton pump inhibitor (PPI) exposure to hypomagnesemia. Whether PPI exposure increases the risk for arrhythmias has not been well studied. Using a large, single-center inception cohort of critically ill patients, we examined whether PPI exposure was associated with admission electrocardiogram readings of a cardiac arrhythmia in more than 8000 patients. There were 25.4% PPI users, whereas 6% were taking a histamine 2 antagonist. In all, 14.0% had a cardiac arrhythmia. PPI use was associated with an unadjusted risk of arrhythmia of 1.15 (95% CI,1.00–1.32; P =.04) and an adjusted risk of arrhythmia of 0.91 (95% CI, 0.77–1.06; P =.22). Among diuretic users (n = 2476), PPI use was similarly not associated with an increased risk of cardiac arrhythmia. In summary, in a large cohort of critically ill patients, PPI exposure is not associated with an increased risk of cardiac arrhythmia.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1002/jcph.479
