Neutrophil Responses to Sterile Implant Materials
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Jhunjhunwala-2015-Neutrophil Responses.pdf
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4.89 MB
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Author(s)
Jhunjhunwala, Siddharth
Tang, Katherine
Alvarez, David
Tang, Benjamin C.
Lavin, Danya M.
Veiseh, Omid
Bose, Suman
Vegas, Arturo
Ma, Minglin
Sahay, Gaurav
Date Issued
September 2015
Journal
PLOS ONE
Publisher
Public Library of Science
Citation
Jhunjhunwala, Siddharth, Stephanie Aresta-DaSilva, Katherine Tang, David Alvarez, Matthew J. Webber, Benjamin C. Tang, Danya M. Lavin, et al. “Neutrophil Responses to Sterile Implant Materials.” Edited by Nades Palaniyar. PLOS ONE 10, no. 9 (September 10, 2015): e0137550.
Version
Final published version
Abstract
In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of the first immune cells to be recruited to implantation sites, have been suggested to contribute to the establishment of the inflammatory microenvironment that initiates the fibrotic response. However, the precise numbers and roles of neutrophils in response to implanted devices remains unclear. Using a mouse model of peritoneal microcapsule implantation, we show 30–500 fold increased neutrophil presence in the peritoneal exudates in response to implants. We demonstrate that these neutrophils secrete increased amounts of a variety of inflammatory cytokines and chemokines. Further, we observe that they participate in the foreign body response through the formation of neutrophil extracellular traps (NETs) on implant surfaces. Our results provide new insight into neutrophil function during a foreign body response to peritoneal implants which has implications for the development of biologically compatible medical devices.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1371/journal.pone.0137550
