Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications
Name
Irvine_Guiding principles.pdf
Size
814.22 KB
Format
Adobe PDF
Checksum (MD5)
8982a8f5cbab0e16b2388c598acaca37
Author(s)
Liu, Haipeng
Irvine, Darrell J
Date Issued
May 2015
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Citation
Liu, Haipeng, and Darrell J. Irvine. “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications.” Bioconjugate Chemistry 26, no. 5 (May 20, 2015): 791–801. © 2015 American Chemical Society
Version
Author's final manuscript
Abstract
Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Ragon Institute of MGH, MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/acs.bioconjchem.5b00103
