Co-evolution and Co-speciation of Host-Gut Bacteria Systems
Name
1-s2.0-S1931312820303541-main.pdf
Description
Published version
Size
1.06 MB
Format
Unknown
Checksum (MD5)
3a50703b93075b7a7c9575f60d5cf3e8
Author(s)
Groussin, Mathieu
Mazel, Florent
Alm, Eric J.
Date Issued
July 2020
Journal
Cell Host & Microbe
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Authors Mammalian gut microbiomes profoundly influence host fitness, but the processes that drive the evolution of host-microbiome systems are poorly understood. Recent studies suggest that mammals and their individual gut symbionts can have parallel evolutionary histories, as represented by their congruent phylogenies. These “co-phylogenetic” patterns are signatures of ancient co-speciation events and illustrate the cohesiveness of the mammalian host-gut microbiome entity over evolutionary times. Theory predicts that co-speciation between mammals and their gut symbionts could result from their co-evolution. However, there is only limited evidence of such co-evolution. Here, we propose a model that explains cophylogenetic patterns without relying on co-evolution. Specifically, we suggest that individual gut bacteria are likely to diverge in patterns recapitulating host phylogeny when hosts undergo allopatric speciation, limiting inter-host bacterial dispersal and genomic recombination. We provide evidence that the model is empirically grounded and propose a series of observational and experimental approaches to test its validity.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.chom.2020.06.013
