Copper-Catalyzed Regioselective Ortho C-H Cyanation of Vinylarenes
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Buckwald_Copper-catalyzed.pdf
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Author(s)
Yang, Yang
Buchwald, Stephen Leffler
Date Issued
May 2014
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Yang, Yang, and Stephen L. Buchwald. “Copper-Catalyzed Regioselective Ortho C-H Cyanation of Vinylarenes.” Angew. Chem. Int. Ed. 53, no. 33 (May 6, 2014): 8677–8681.
Version
Author's final manuscript
Abstract
A copper-based catalytic technique for the regioselective ortho C-H cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1002/anie.201402449
