Hydrogel cell encapsulation for tissue engineering
Name
297119482-MIT.pdf
Description
Full printable version
Size
23.48 MB
Format
Adobe PDF
Checksum (MD5)
2826d188df1a974db63a8f26074851d1
Author(s)
Ling, Yibo
Advisor(s)
Ali Khademhosseini and Martha Gray.
Date Issued
2008
Publisher
Massachusetts Institute of Technology
Abstract
The engineering of artificial tissues for restoration or replacement of organ function holds the potential to alter the landscape of medical therapeutics. In many tissue engineering approaches, cells seeded within 3D porous structures are expected to remodel into tissue-like structures. Despite significant progress, difficulties in lack of control over tissue architecture as well as vascularization continue to limit the efficacy of engineered constructs. This thesis describes work aimed at tackling these two problems. First, two techniques for generating size- and shape-controlled cell-laden hydrogels are described in the context of potential modular assembly for conferring greater control over the geometry of homotypic and heterotypic cell arrangements within engineered tissues. Then, a method for producing cell-loaded microfluidic agarose hydrogels for tissue engineering is described.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.
Vita.
Includes bibliographical references (leaves 116-123).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
M.I.T. theses are protected by
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
copyright. They may be viewed from this source for any purpose, but
reproduction or distribution in any format is prohibited without written
permission. See provided URL for inquiries about permission.
Persistent DSpace Link
