Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
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Poly(glycoamidoamine) Brushes.pdf
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1.79 MB
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Checksum (MD5)
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Author(s)
Abutbul-Ionita, Inbal
Danino, Dganit
DeRosa, Frank
Heartlein, Michael
Dong, Yizhou
Dorkin, Joseph Robert
Wang, Weiheng
Webber, Matthew
Tang, Benjamin C.
Yang, Jung H
Date Issued
January 2014
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dong, Yizhou et al. “Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.” Nano Letters 16.2 (2016): 842–848.
Version
Author's final manuscript
Abstract
Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII and mRNA-encoding erythropoietin (EPO) in mice. Importantly, these nanoparticles were well-tolerated at their effective dose based on analysis of tissue histology, systemic cytokine levels, and liver enzyme chemistry. The polymer brush nanoparticles reported here are promising for therapeutic applications.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acs.nanolett.5b02428
