Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine
Name
1197978944-MIT.pdf
Size
12 MB
Format
Adobe PDF
Checksum (MD5)
6b659b4694d05c29d33ac2233effac71
Author(s)
Le, Serena.
Advisor(s)
Alexander H. Slocum.
Date Issued
2020
Publisher
Massachusetts Institute of Technology
Abstract
Lyophilization, or freeze drying, of unit-dose pharmaceuticals eliminates the need to preserve quality through regulated temperature storage during transport. Typical lyophilization is performed through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a load lock system. Load lock systems, commonly used in the semiconductor industry, act as a transfer chamber in order to reduce pump-down and venting time of its adjacent processing chambers. This thesis documents the research and design of a load lock system for a continuous manufacturing lyophilization machine.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 65-66).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
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