Process intensification and optimization for hydroxyapatite nanoparticles production
Name
Processintensificationandoptimizationforhydroxyapatitenanoparticlesproduction_preprint.pdf
Description
Accepted version
Size
1.41 MB
Format
Adobe PDF
Checksum (MD5)
dff7f74e87273ebc3c0029ff92de06cf
Author(s)
Castro, Filipa
Kuhn, Simon
Jensen, Klavs
Ferreira, António
Rocha, Fernando
Vicente, António
Teixeira, José António
Date Issued
2013
Journal
Chemical Engineering Science
Publisher
Elsevier BV
Citation
Castro, F., et al. "Process Intensification and Optimization for Hydroxyapatite Nanoparticles Production." Chemical Engineering Science (2013).
Version
Author's final manuscript
Abstract
Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas-liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower. © 2013 Elsevier Ltd.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.ces.2013.01.002
