Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
Name
Puig-2014-Dopamine modulation.pdf
Size
1.76 MB
Format
Adobe PDF
Checksum (MD5)
db6958b7d69bb44bdf6512aaa590a5d8
Author(s)
Puig, M. Victoria
Rose, Jonas
Schmidt, Robert
Freund, Nadja
Date Issued
August 2014
Journal
Frontiers in Neural Circuits
Publisher
Frontiers Research Foundation
Citation
Puig, M. Victoria, Jonas Rose, Robert Schmidt, and Nadja Freund. “Dopamine Modulation of Learning and Memory in the Prefrontal Cortex: Insights from Studies in Primates, Rodents, and Birds.” Front. Neural Circuits. 8 (August 5, 2014).
Version
Final published version
Abstract
In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fncir.2014.00093
