Microfluidic technologies for accelerating the clinical translation of nanoparticles
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Langer_Microfluidic technologies.pdf
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Author(s)
Langer, Robert
Valencia, Pedro Miguel
Farokhzad, Omid C.
Karnik, Rohit
Langer, Robert
Date Issued
October 2012
Journal
Nature Nanotechnology
Publisher
Nature Publishing Group
Citation
Valencia, Pedro M., Omid C. Farokhzad, Rohit Karnik, and Robert Langer. Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles. Nature Nanotechnology 7, no. 10 (October 8, 2012): 623-629.
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Author's final manuscript
Abstract
Using nanoparticles for therapy and imaging holds tremendous promise for the treatment of major diseases such as cancer. However, their translation into the clinic has been slow because it remains difficult to produce nanoparticles that are consistent 'batch-to-batch', and in sufficient quantities for clinical research. Moreover, platforms for rapid screening of nanoparticles are still lacking. Recent microfluidic technologies can tackle some of these issues, and offer a way to accelerate the clinical translation of nanoparticles. In this Progress Article, we highlight the advances in microfluidic systems that can synthesize libraries of nanoparticles in a well-controlled, reproducible and high-throughput manner. We also discuss the use of microfluidics for rapidly evaluating nanoparticles in vitro under microenvironments that mimic the in vivo conditions. Furthermore, we highlight some systems that can manipulate small organisms, which could be used for evaluating the in vivo toxicity of nanoparticles or for drug screening. We conclude with a critical assessment of the near- and long-term impact of microfluidics in the field of nanomedicine.
MIT Department
MIT-Harvard Center for Cancer Nanotechnology Excellence
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nnano.2012.168
