Force transmission in epithelial tissues
Name
Force transmission.pdf
Size
918.54 KB
Format
Adobe PDF
Checksum (MD5)
f345f9034a7aaef14d31c0f2613e35c4
Author(s)
Vasquez, Claudia G.
Martin, Adam C.
Date Issued
March 9, 2017
Journal
Developmental Dynamics
Publisher
Wiley Blackwell
Citation
Vasquez, Claudia G., and Adam C. Martin. “Force Transmission in Epithelial Tissues: Force Transmission in Epithelial Tissues.” Developmental Dynamics 245.3 (2016): 361–371.
Version
Author's final manuscript
Abstract
In epithelial tissues, cells constantly generate and transmit forces between each other. Forces generated by the actomyosin cytoskeleton regulate tissue shape and structure and also provide signals that influence cells' decisions to divide, die, or differentiate. Forces are transmitted across epithelia because cells are mechanically linked through junctional complexes, and forces can propagate through the cell cytoplasm. Here, we review some of the molecular mechanisms responsible for force generation, with a specific focus on the actomyosin cortex and adherens junctions. We then discuss evidence for how these mechanisms promote cell shape changes and force transmission in tissues.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/dvdy.24384
